Another study using the same approach identified a potential miRNA fingerprint in L1CAM+ NDEVs from plasma of ALS patients (containing miR-146a-5p, miR-199a-3p, miR-151a-3p, miR-151a-5p, and miR-199a-5p) that showed up-regulation in ALS patients compared with healthy controls, while 3 miRNAs (miR-4454, miR-10b-5p, and miR-29b-3p) were down-regulated in ALS [191]. This evidence concerns the gene L1CAM and amyotrophic lateral sclerosis.