MAPT and Alzheimer disease: As accumulation of Aβ deposits and formation of neurofibrillary tangles composed of p-Tau in the brain are major pathological hallmarks of AD, neuroimaging approaches including magnetic resonance imaging (MRI) and positron emission tomography (PET), and CSF examinations that detect Aβ (Aβ1–42 and Aβ1–40) and p-Tau, are used as the gold-standard for AD diagnosis [170].