Scientists have reported that the levels of NADH ubiquinone oxidoreductase core subunit S3 (NDUFS3) and succinate dehydrogenase complex subunit B (SDHB) are significantly lower in L1CAM+ NDEVs isolated from the plasma of type 2 diabetes mellitus (T2DM) patients with AD dementia and progressive mild cognitive impairment (MCI) patients than in cognitively healthy individuals [182]. This evidence concerns the gene L1CAM and diabetes mellitus.