AUC values of the ROC curve for plasma-isolated SNAP25+ NDEVs, EAAT1+ ADEVs, and OMG+ ODEVs were 0.82, 0.75, and 0.78, respectively, indicating the capability of the plasma levels of brain-derived EVs as diagnostic biomarkers for PD. The gene discussed is SLC1A3; the disease is Parkinson disease.