TREM2 and Alzheimer disease: Besides Aβ and p-Tau, shotgun proteomics studies have demonstrated a significant decrease in the abundance of homeostatic microglia markers P2RY12 and TMEM119, and increased levels of AD-associated factors FTH1 and TREM2 in CD11b+ MDEVs isolated from cryopreserved human brain tissues of AD patients, compared with age-matched normal/low pathology cases [112].