ESR1 and neoplasm: A fine needle aspiration and core needle biopsy of the liver showed an ER negative, PR negative, HER2 2+ by immunohistochemistry (IHC) and positive by FISH group 3 by ASCO CAP 2018 (copy number 7.9 and ratio 1.61) tumor (Fig. 1K and Fig. 3) [10].