By using TNM plot [24], we found that expression of several complex III components (data were available for CYCS, CYC1, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRQ, UQCR10, UQCR11) and assembly factors (BCS1L, UQCC1, TTC19) is decreased in colon tumor tissues compared to the normal tissue, and is further decreased in metastatic tumors compared to the primary ones (Fig. 4A–C). This evidence concerns the gene CYCS and metastatic neoplasm.