CRYAB and lobular neoplasia: Since HSPB5 dampens monocyte/macrophage-dependent inflammatory responses, combining HSPB5 treatment with an anti-CD20 antibody such as rituximab or obinutuzumab, which have been shown to reduce anti-dsDNA antibody titers and cause B cell depletion in LN patients [47, 48], represents an attractive strategy to improve renal response rates.