In this study, we used NZB/W F1 mice, a classic model of SLE with aberrant innate signaling and macrophage activity, to compare the efficacy of HSPB5 to a standard of care SLE medication, methylprednisolone, and to investigate the immune cell and inflammatory marker changes in the kidneys during HSPB5 treatment. Here, CRYAB is linked to systemic lupus erythematosus.