MBNL1 and myotonic dystrophy type 1: MBNL1 sequestration by abnormally expanded CUG repeats is key to the clinical symptoms in DM1 [8], but this multi-systemic disease has also been found to be related with many other factors, such as increased CELF [45] or HNRNPA1 [46] expression, and decreased DMPK, SIX5, and DMWD expression [47].