These potent tumour suppressor effects can be ascribed to the presence of an abundance of anti-angiogenic factors (maspin, thrombospondin-1, TIMP-1, soluble bFGF receptors, and prolactin and plasminogen fragments) that are found in the myoepithelial xenograft extracts which play an essential role in shielding against cancer dissemination [33]. This evidence concerns the gene SERPINB5 and neoplasm.