Furthermore, when compared to the infected-control group, chalcones treated groups (derivative 1, 2, and 3) and CQ showed significant reductions in IL-6 and IL-1 levels, while other cytokines such as IL-1 and IFN- γ levels were comparatively low in CQ treated and derivative 1 treated groups, indicating protection against disease progression and modulating the immune response in the P. berghei infected malaria mouse model. Here, IL1B is linked to malaria.