We found that with the development of gastroesophageal varices, the total bilirubin (TBIL), liver stiffness (LS), serum liver fibrosis markers (hyaluronic acid, laminin, type III procollagen, and type IV collagen), aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis 4 score (FIB-4) were also increased significantly, as shown in Table 2. The gene discussed is LAMB2; the disease is Hepatic fibrosis.