Finally, Vagrecha et al. (2022) used a monogenic autoimmunity panel to investigate genetic variations in 109 genes crucial to immune regulation amongst children with MIS-C, from whom 25.4% exhibited rare heterozygous variants of unknown significance in primary hemophagocytic lymphohistiocytosis genes (LYST, STXBP2, PRF1, UNC13D, AP3B1) or the hemophagocytic lymphohistiocytosis-associated DOCK8 gene (Vagrecha et al. 2022). Here, PRF1 is linked to COVID-19–associated multisystem inflammatory syndrome in children.