IFNA1 and COVID-19–associated multisystem inflammatory syndrome in children: Furthermore, rare inborn errors of immunity (IEIs) perturbing the immune response to SARS-CoV-2 and dysregulation of type I interferons (IFN)s immunity were proposed to underlie the MIS-C pathogenesis in some children (Sancho-Shimizu et al. 2021; Abolhassani et al. 2022).