Thus, seipin could interfere in the capacity of macrophages to respond to pathogens through the lipid droplet metabolism and one-third of patients with congenital generalised lipodystrophy, a recessive condition caused by BSCL2 variants, died of infectious disease (Zhou et al. 2022). Although patient EXOC18 had no noticed lipodystrophy previous to MIS-C, BSCL2 variants are also described in dominant clinical conditions (OMIM), which could explain the higher susceptibility to MIS-C. Here, BSCL2 is linked to lipodystrophy.