Taken together, these data suggest that the reduction of Lepr signaling in the LH plays a substantial role in eliciting the binge-like eating habits and tendency toward HFD-induced obesity as well as the consistent enhancement in c-fos expression over the multiple Re-HFD cycles, mirroring the various features we observed in ELT mice. Here, FOS is linked to obesity due to melanocortin 4 receptor deficiency.