In one older study, young age, increased white blood cell count, a prominent monocytic component, core-binding factor (CBF) AML (i.e., inversion 16 or t [8, 21]), chromosome 11q23 abnormalities, trisomy 8, and FLT3-ITD mutations may be associated with increased risk of CNS involvement. The gene discussed is FLT3; the disease is acute myeloid leukemia.