Besides, MSI2 protein and mRNA levels were significantly recovered upon SOX11 ectopic overexpression in Z138-SOX11KO cell line (Z138-SOX11KO SOX11+) (Supplementary Fig. S3A, B, respectively), indicating the implication of SOX11 in the transcriptional upregulation of MSI2 in MCL cells. Here, MSI2 is linked to mantle cell lymphoma.