In bivariate COX regression analyses, the adverse OS prognostic value of MSI2 was independent of different high-risk MCL features, such as SOX11 expression, high copy number alterations (≥6 CNA), TP53 (17p13.1) and CDKN2A (9p21.3) alterations (Table 1). Here, CDKN2A is linked to mantle cell lymphoma.