To have a more comprehensive understanding of the mechanisms underlying MSI2 upregulation, we analyzed the epigenetic profile of the MSI2 locus using reference epigenomes, comparing two SOX11+ and three SOX11– MCL cases, Z138 (SOX11+) and JVM2 (SOX11–) MCL cell lines, and naive (NBC) and memory B cells (MBC) [7, 33, 34]. The gene discussed is SOX11; the disease is mantle cell lymphoma.