CDK6 and NOTCH1, important genes in stemness [36–38] and MCL pathogenesis [39, 40], were identified as MSI2-direct targets in long-term hematopoietic stem cells (LT-HSCs) [41] and possible targets in MCL, as they were differentially expressed upon MSI2KD in Z138 cell line (Supplementary Fig. S6A). This evidence concerns the gene NOTCH1 and mantle cell lymphoma.