Noteworthy, is that despite the severe male infertility phenotype of the Dcaf17 mutants the separation in the PCA plot and in the heat map (Fig. 1A, B) is not as dramatic as anticipated, therefore, highlighting the critical importance of the DEGs for male fertility, and potentially suggesting that Dcaf17 impacts the proteome more severely than the transcriptome. This evidence concerns the gene DCAF17 and male infertility.