PRDM9 and Infertility: Additional epigenetic factors such as Hdacs and DNA methyltransferase Dnmt3a were also altered in 3 weeks old mice, including histone methyltransferase Rbbp5 and arginine/histone methlytransferase Prmt7, suggesting that chromatin modifications in Dcaf17 mutants might be severely altered and could potentially be a major cause for the Dcaf17−/− infertility through impaired chromosome condensation.