Consistent with the patterns of MYCL/MYCN amplification in the SCLC-A subtype and MYC amplification in the SCLC-N subtype8,46, the expression of ASCL1 and NEUROD1 in SCLC cell lines representing the SCLC-A and SCLC-N subtypes was dependent on LSD1 activity56. The gene discussed is ASCL1; the disease is small cell lung carcinoma.