Monitoring tumor formation in NSCLC GEMMs of lung adenocarcinoma (KPS: KrasLSL-G12D/+; Trp53lox/lox; Smarca4lox/lox) revealed that regardless of the cell type in which the alleles were targeted (alveolar type II epithelial cells or club cells), Smarca4 loss led to increased metastasis87. The gene discussed is SMARCA4; the disease is non-small cell lung carcinoma.