After evaluating our mouse model, we were able to show that the group that was administered AngII at a dose of 2500 ng/kg/min for 2 weeks had a significantly higher incidence of AD formation compared to mice treated with BAPN combined with 1000 ng/kg/min AngII for 4 weeks and a similar cumulative survival rate compared to mice treated with BAPN combined with 2500 ng/kg/min AngII for 4 weeks. The gene discussed is AGT; the disease is Alzheimer disease.