AGT and Alzheimer disease: In the vehicle group, the mice challenged with more than 2000 ng/kg/min AngII (OR 18.80, 95% CI 5.62–62.87, P < 0.00001, I2 = 0%) could increase the success rate of the mouse AD model compared with the mice challenged with 1000 ng/kg/min AngII (OR 11.81, 95% CI 3.75–37.20, P < 0.0001, I2 = 0%) (Table 4).