Reducing the use time of AngII from 28 to 14 days is not only for cost savings but also because we have verified that shortening the modeling time can achieve similar modeling success rates, while the cumulative mortality of mice decreases, which may allow researchers to obtain more aortic tissue from mice with aortic dissection, which is necessary for the study of aortic dissection. The gene discussed is AGT; the disease is dissection.