Then through the gross observation of the aortic tissue dissected from mouse anatomy and HE and EVG staining(Fig. 1C,D and Supplementary Fig. 1D), we found that the incidence of AD in the group infused with AngII at a dosage of 2500 ng/kg/min for 4 weeks was 60% (6/10, 4 thoracic aortic dissection (TAD) and 5 abdominal aortic dissection (AAD) ) and was also 60% (12/20, 7 TAD and 11 AAD) in the group infused with AngII at a dosage of 2500 ng/kg/min for 2 weeks, while the group infused with 1000 ng/kg/min AngII for 4 weeks was 20% (2/10, 1 TAD and 2 AAD) (Fig. 1E and Supplementary Fig. 1B,C). The gene discussed is AGT; the disease is Alzheimer disease.