AGT and Alzheimer disease: To more accurately compare the effects of different doses of AngII and their use time on the success rate of inducing mouse AD model, we carried out the meta-analysis and concluded that using AngII less than 14 days at a dose of greater than 2000 ng/kg/min could induce a higher incidence of AD formation and a lower cumulative survival rate, and we validated this result with our own animal experiments.