Reassuringly, this analysis (Fig. 2 and Supplementary Data 1) identified Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome pathways previously associated with physiological aging, such as proteoglycans/chondroitin sulfate and extracellular matrix reorganization, signaling pathways p53, PI3K-AKT, MAPK, HIF-1 and WNT, apoptosis, and Alzheimer’s disease. Here, TP53 is linked to early-onset autosomal dominant Alzheimer disease.