ARL1 and cancer: Coordinately spliced ND in the GTPases involved in vesicle trafficking (ARL1 and RAB family genes), TRD in the endoplasmic reticulum-associated proteins involved in the ceramide/inositol synthesis (CDITP, CERS2, KDSR, etc.)and synaptic proteins involved in neuronal signaling (DAGLB, KCNN2, MCTP1, etc.)suggests the coordination in post-natal neuronal function such as setting up and firing rapid action potentials (Fig. 7b, right panel) and loss thereof in cancer (Fig. 7b and Supplementary Fig. 6b).