Coordinately spliced ND in the GTPases involved in vesicle trafficking (ARL1 and RAB family genes), TRD in the endoplasmic reticulum-associated proteins involved in the ceramide/inositol synthesis (CDITP, CERS2, KDSR, etc.)and synaptic proteins involved in neuronal signaling (DAGLB, KCNN2, MCTP1, etc.)suggests the coordination in post-natal neuronal function such as setting up and firing rapid action potentials (Fig. 7b, right panel) and loss thereof in cancer (Fig. 7b and Supplementary Fig. 6b). The gene discussed is CERS2; the disease is cancer.