Chen et al (2017a) demonstrated that ARF, a tumor suppressor protein, directly interacts with NRF2 both in vitro and in the xenograft tumor model, where loss of ARE induces NRF2 activation followed by elevation of SLC7A11 expression and promotion of resistance to ROS-induced ferroptosis and cancer cell survival in p53 null cells. The gene discussed is NFE2L2; the disease is neoplasm.