NRF2 knockdown in non-small cell lung cancer cell lines promoted radiation-induced cell apoptosis, where interestingly, NOTCH1 expression under radiation exposure was decreased significantly by depletion of NRF2, implying that NOTCH-NRF2 signaling crosstalk might be correlated with apoptosis resistance in cancer cells (Zhao et al, 2016). This evidence concerns the gene NFE2L2 and cancer.