NFE2L2 and lung cancer: This was also verified in mouse models of pancreatic and lung cancer that expressed these oncogenes and exhibited increased Nqo1 expression (a prototypical NRF2 target gene) and reduced oxidative stress, as evidenced by low 7,8-Dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo) levels (DeNicola et al, 2011).