It has been shown that NRF2 regulates the expression of serine/glycine biosynthesis genes (PHGDH, PSAT1, SHMT2) via ATF4 in non-small-cell lung cancer cell lines and thus can support the proliferation of cancer cells (DeNicola et al, 2015). This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.