An approach to unravel mechanisms underlying the NRF2-mediated cell proliferation in non-small-cell lung cancers was performed using three distinct cell lines: A549 that has a point mutation of KEAP1 and a wild-type epidermal growth factor receptor (EGFR), PC-9 cells that have no mutation of KEAP1 but an activating deletion in EGFR, and NCI-H292 cells that possess wild-type KEAP1 and EGFR (Yamadori et al, 2012). Here, NFE2L2 is linked to non-small cell lung carcinoma.