No toxicity or alteration in levels of renal fibrosis was seen in uninjured control kidneys treated with Loc14 versus vehicle (Supplemental Figure 7F), and inhibition did not affect senescent cell number, as measured by Cdkn1a or Cdkn2a via qPCR or P21CIP1 expression on immunofluorescence (Supplemental Figure 8, C and D). The gene discussed is CDKN1A; the disease is renal fibrosis.