TSN and colorectal carcinoma: Recent studies have shown that TSN possesses antitumor effects in various cancers, such as triple-negative breast cancer (TNBC), glioma, ovarian cancer, liver cancer, CRC, by regulating c-Myc, PI3K/AKT/mTOR, and NF-κB, which are strongly correlated with STAT3 (52–55).