Incubation of OVCAR3-FSHR target cells plus human PBMCs with D2AP11-TCE led to the significant induction of IFN-γ, soluble Fas (sFas), granzyme A, granzyme B, and perforin compared with empty vector control at 48 hours, and this construct drove robust tumor antigen-specific killing (Figure 8A). The gene discussed is PRF1; the disease is neoplasm.