In this chronic colitis model, Phd1–/– mice showed significantly attenuated colitis activity compared with WT control animals as assessed by the BW change and disease activity index (DAI) (Figure 1B, and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.153337DS1). This evidence concerns the gene EGLN2 and colitis.