Phd2 reduces the number of TAMs and expression of protumorigenic epiregulin (Ereg) in both BM-derived macrophages (BMDMs) and AOM/DSS tumors, and, thus, at least in part contributes to the suppression of the oncogenic signal transducer and activator of transcription 3 (STAT3) and extracellular signal–regulated kinase 1/2 (ERK1/2) signaling pathways in the AOM/DSS model. Here, STAT3 is linked to infectious otitis media.