Consistent with this, interrogation of Ereg expression in 2 large-scale single-cell RNA-Seq (scRNA-Seq) data sets of human CRC and UC (Broad Institute) (36, 37) verified that Ereg was also expressed in human macrophages and monocytes (Figure 5, B and C), underscoring the importance of EREG in these cells for CAC. This evidence concerns the gene EREG and colorectal carcinoma.