Consistently, tumor proliferation, apoptosis, and STAT3 phosphorylation (Supplemental Figure 7, C–E), as well as gene expression of Ereg (Supplemental Figure 7F), IL-6, and IL-11 (Supplemental Figure 7G), were not significantly altered in Villin:Cre-Phd2fl/fl mice as compared with the controls. This evidence concerns the gene STAT3 and neoplasm.