Since immune cells, and specifically myeloid cells such as macrophages, are key determinants of tumor growth in the AOM/DSS model (34), we comprehensively profiled the immune cell landscape of AOM/DSS-induced tumors of Phd2+/– and WT controls using flow cytometry (Supplemental Figure 4A, and Supplemental Figure 5A). The gene discussed is EGLN1; the disease is infectious otitis media.