However, these previous studies focused solely on tumor cell–autonomous effects of PHD3 in heterotopic or orthotopic tumor models (21, 22), while in our present study we subjected global Phd3-KO mice to colitis-associated and sporadic colorectal tumor models, thus assessing the biological relevance of PHD3 in both tumor cells and the tumor microenvironment (TME). This evidence concerns the gene EGLN3 and colorectal neoplasm.