Intriguingly, after 140 days, tumor number and size were equal in Phd1–/–, Phd2+/–, Phd3–/–, and WT control mice (Figure 2F), indicating that in the absence of underlying intestinal inflammation, the loss of any of the PHD isoenzymes does not result in differences concerning tumor number or size of sporadic CRC. This evidence concerns the gene EGLN1 and neoplasm.