EGLN1 and neoplasm: Strikingly, supernatant of Phd2+/– BMDMs stimulated with LPS or IL-4 significantly increased tumor cell viability of CMT-93 cells compared with treatment with supernatant of WT BMDMs stimulated with LPS or IL-4, indicating that Phd2+/– macrophages can promote tumor growth in vitro (Figure 5D).