However, these previous studies focused solely on tumor cell–autonomous effects of PHD3 in heterotopic or orthotopic tumor models (21, 22), while in our present study we subjected global Phd3-KO mice to colitis-associated and sporadic colorectal tumor models, thus assessing the biological relevance of PHD3 in both tumor cells and the tumor microenvironment (TME). Here, EGLN3 is linked to neoplasm.