CD4-neighbouring SIGLEC8 RNA molecules were also significantly associated with NF-κB (NFKB1) and IFNγ (IFNGR1, STAT1 and IRF1) signalling components (Fig. 4i and Extended Data Fig. 8j), which indicates that the same pathways might drive interactions between A-Eos and CD4+ T cells in mouse and human colitis. The gene discussed is CD4; the disease is colitis.