NFKB1 and cancer: Transgenic interference with NFκB signaling substantially reduced loss of muscle mass across nearly every model investigated, including unloading, immobilization, denervation, acute inflammatory challenge, nutrient deprivation, and cancer (Cai et al., 2004; Mourkioti et al., 2006; Judge et al., 2007; Van Gammeren et al., 2009; Reed et al., 2011; Haegens et al., 2012; Langen et al., 2012; Lee and Goldberg, 2015).