PDGFRB and Stroke: In this context, administration of supraphysiologic levels of rhPDV has been found to reduce BBB dysfunction while promoting BBB repair by inducing the migration and proliferation of platelet-derived growth factor receptor β (PDGFRβ) positive pericytes to the ischemic brain following experimental stroke; Nakamura et al. [26] aptly demonstrated that rhPDV maintains the BBB by its simultaneous interaction with α5β1 integrin and PDGFRβ to regulate focal adhesion and actin cytoskeleton in the ischemic tissue.