In this context, administration of supraphysiologic levels of rhPDV has been found to reduce BBB dysfunction while promoting BBB repair by inducing the migration and proliferation of platelet-derived growth factor receptor β (PDGFRβ) positive pericytes to the ischemic brain following experimental stroke; Nakamura et al. [26] aptly demonstrated that rhPDV maintains the BBB by its simultaneous interaction with α5β1 integrin and PDGFRβ to regulate focal adhesion and actin cytoskeleton in the ischemic tissue. Here, PDGFRB is linked to stroke disorder.