HMGCL and neoplasm: Genomic enrichment analysis (GSEA) of this proteomic data showed that the low expression of HMGCL was associated with oncogenic EMT and E2F signaling (Supplementary Fig. S1D, E), whereas the enriched dataset with high HMGCL was associated with bile acid metabolism and peroxisome, which are involved in anti-tumor activity (Supplementary Fig. S1F, G) [27, 28].