HMGCL and hepatocellular carcinoma: To investigate the suppressive proteins in the HCC process, we analyzed the differential proteome profile between HCC tissues and paired adjacent tissues from 101 early-stage HCC patients published previously [26], HMGCL was identified to be enriched in 6 of top 10 biological processes in down-regulated protein dataset by gene ontology (GO) analysis (Supplementary Fig. S1A).