To further examine HMGCL functions in the cancerization course from normal hepatocytes to cancer cells in vivo, we generated hepatocyte-specific deletion of Trp53 mice (Trp53Δhep/Δhep) by crossing Trp53flox/flox with Alb-Cre mice, which mimicked 58% of HCC patients possessing the Trp53 mutation as previously described previously [29]. The gene discussed is TP53; the disease is hepatocellular carcinoma.