HNF4A and hepatocellular carcinoma: All the tumor sections were positively stained by hepatocyte lineage marker HNF4α, and negatively stained by cholangiocyte lineage marker KRT19 (Supplementary Fig. S4D), demonstrating that Trp53Δhep/Δhep and c-Myc-driven tumors were HCC instead of intrahepatic cholangiocarcinomas.