While some tumor types, such as bladder urothelial carcinoma and uterine corpus endometrial carcinoma, showed elevated HMGCL expression, other tumor types, such as pheochromocytoma and para-ganglioma as well as cholangial carcinoma, showed decreased HMGCL expression (Fig S2A, B). This evidence concerns the gene HMGCL and hereditary pheochromocytoma-paraganglioma.