The univariate analysis showed that baseline age, unemployment, higher depression and anxiety symptoms, a history of psychiatric disorders, lower current CD4 count, lower current CD4:CD8 ratio, longer duration on ART, HIV brain involvement burden (combination of historical and baseline HIV brain involvement), current abacavir containing regimen, current efavirenz containing regimen, current atazanavir containing regimen, and current darunavir containing regimen were associated with a higher risk of developing the combined ARC at p value < 0.1. The gene discussed is CD8A; the disease is major depressive disorder.