MAPK8 and urinary bladder carcinoma: In colorectal cancer, MEX3C has been identified as an unstable gene that is frequently lost in CIN+ (cervical intraepithelial neoplasia+) [40, 41], and this protein was shown to regulate lipid metabolism through the JNK (c-Jun N-terminal kinase) pathway in bladder cancer [42] and breast cancer [43].