Macrophages are activated and polarized to M1‐like (usually proinflammatory) or M2‐like (usually anti‐inflammatory) states in response to environmental factors.[2, 5] We found that in the OVX osteoporosis mice, the percentage of CD80+F4/80+ M1 phenotype macrophages was significantly increased compared to that of sham mice (Figure 3a). The gene discussed is CD80; the disease is osteoporosis.