SCD and alopecia: Consistent with previous observations, loss of Scd1 resulted in a series of cutaneous abnormalities, including alopecia.[20, 21, 22] Here, we demonstrate that Scd1 deficiency did not directly influence the number and activity of HFSCs, but rather impaired the formation of the first bulge during the postnatal period, leading to the depletion of HFSC reservation during hair growth.