CXCL6 and osteoarthritis: While outside the scope of this work, it is reasonable to speculate that the embryonic expression of GCP‐2 in the prospective articular cartilage may contribute to its capacity to resist endochondral bone formation during development, whereas, in adult life, contributes to the prevention of mineralization and hypertrophic differentiation which are pathologic features in osteoarthritis (Saito et al, 2010).