• Positive RA-related auto antibodies (Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) or Anti-carbamylated antibodies) • Clinically suspect arthralgia (CSA) Inflammatory clinical features such as difficult making a fist, a positive squeeze test or early morning stiffness (EMS) • Subclinical inflammation on imaging. This evidence concerns the gene PRTN3 and rheumatoid arthritis.