Also, other full length IgG specific monoclonal antibody (113-5B7) coupled to fluorescent label rhodamineX, 111In-labeled miniaturized antibodies such as a scFv and a dimer of two molecules of scFv (diabody) and peptides conjugated with near-infrared fluorescent (NIRF) dye Cy5.5 or 99mTc have been explored for monitoring MT1-MMP in several cancers by SPECT and optical imaging (32–35). Here, MMP14 is linked to cancer.