In previous works, we have developed antibody-based approaches for PET imaging of MT1-MMP in glioma and pancreatic cancer based on the murine anti-MT1-MMP monoclonal antibody LEM2/15 (17, 18) illustrating the high potential of MT1-MMP as imaging-based biomarker for detection of several cancer types. This evidence concerns the gene LEMD2 and glioma.