The different regions of the skin under black hair also had differential enrichment (2–8) of KEGG signaling pathways in the VEGF signaling pathway, glutathione metabolism, amoebiasis, etc. In addition, WGP_w1 and WGP_w2 (scatter plot of KEGG enrichment within the white under-hair skin group) showed that the number of differentially enriched genes in different regions of the white hair base skin was low, such as lysine degradation, porphyrin and chlorophyll metabolism, cocaine addiction and amphetamine lateral sclerosis (ALS) (Figure 4C). The gene discussed is VEGFA; the disease is cocaine dependence.