Here, we have expanded our findings and show for the first time that MIR29B reactivates HBG gene transcription and induces HbF expression by silencing the HBG repressor protein MYB in vitro in KU812 leukemia cells and normal human erythroid progenitors generated from CD34+ stem cells and in the preclinical Townes SCD mouse model. This evidence concerns the gene MYB and leukemia.