Boveda-Ruiz et al. (50) found that Tregs increase the release of TGF-β1 and collagen deposition in the early stages of pulmonary fibrosis, demonstrating that Tregs have a pro-fibrosis effect in the early stages; However, Tregs in the late stage have an anti-fibrotic effect: Xiong et al. (49) studies have shown that the depletion of Tregs can increase Th17 cell expression, thereby prompting the Th1/Th2 balance to shift to Th1, thereby reducing the degree of pulmonary fibrosis. The gene discussed is TGFB1; the disease is pulmonary fibrosis.