TGFB1 and pulmonary fibrosis: Studies confirmed (44) that the neutrophil inhibitor civirolox sodium reduces the degree of pulmonary fibrosis by inhibiting TGF-β expression; In addition, Gregory et al. (45) used bleomycin to induce fibrosis in mice, and found that fibroblasts and myofibroblasts in mice with NE(-/-) were greatly reduced, and the degree of pulmonary fibrosis was less than in the normal group, further confirming that neutrophils are participated in the immune adjustment of IPF.