SPP1 and idiopathic pulmonary fibrosis: As presentation in Figure 10, the diagnostic ability of the three biomarkers in distinguishing IPF from the normal samples showed a advantageous diagnostic value, with an AUC of 0.943 (95% CI 0.883–0.986) in CRTAC1, AUC of 0.886 (95% CI 0.778–0.970) in COL10A1, AUC of 0.984 (95% CI 0.956–1.000) in COMP, AUC of 0.633 (95% CI 0.469–0.782) in RPS4Y1, AUC of 0.936 (95% CI 0.873–0.980) in IGFL2, AUC of 0.925 (95% CI 0.841–0.987) in NECAB1, AUC of 0.967 (95% CI 0.923–0.995) in SCG5, AUC of 0.763 (95% CI 0.625–0.882) in SLC6A4, AUC of 0.886 (95% CI 0.790–0.957) in SPP1.