IL-1β and TNF-α in patients with osteoarthritis can induce and obviously upregulate the expression of CRT in articular chondroblasts or synovial fibroblasts (37), CRTAC1 can be used as a biomarker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells (38). This evidence concerns the gene CRTAC1 and osteoarthritis.