Animal studies have shown that the regulatory mechanism of IH on metabolism may be related to hypoxia-induced epinephrine (Luo et al., 2022), ameliorating insulin resistance via the HIF-insulin signaling pathway (Tian et al., 2016), and recovery of mitochondrial activity (Trzepizur et al., 2015; Table 2). The gene discussed is INS; the disease is Insulin resistance.