For example, a recent ferroptosis study pointed out that thrombin can induce ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion, which suggested thrombin-ACSL4 axis may be an important therapeutic target to ameliorate ferroptotic neuronal injury during ischemic stroke (Tuo et al., 2022). The gene discussed is ACSL4; the disease is ischemic stroke.