Numerous glioma-associated studies have focused on the determination of ferroptosis-related protein expression, such as ACSL4, glutathione peroxidase (GPX4), system Xc–, and ferroptosis suppressor protein 1/AIFM2 (FSP1), etc. Mechanistically, ACSL4 is required for ferroptosis in glioma via the regulation of proliferation, migration of glioblastoma, and self-renewal of glia cells (Cheng et al., 2020; Bao C. et al., 2021; Dattilo et al., 2021). The gene discussed is ACSL4; the disease is central nervous system cancer.