Mashima et al. (2009a) also found that ACSL5 inhibition can synergistically potentiate the glioma cell death induced by etoposide, a well-known activator of apoptosis. In another earlier study, Yamashita et al. (2000) found FA-induced glioma cell growth is mediated by the ACSL5 gene located on chromosome 10q25.1-q25.2, where deletion frequently happened in malignant gliomas. This evidence concerns the gene ACSL5 and malignant glioma.