ACSL1 and amyotrophic lateral sclerosis: The authors analyzed at least 350 samples from 178 ALS patients and 172 athletes (including soccer players, middle- and long-distance runners) and found that the ACSL1 AA genotype was more prevalent among ALS patients and soccer players compared to controls, while ACSL1 GG carriers had a higher mortality rate (Ben-Zaken et al., 2022).