Recently, Qiu et al. (2020) observed significant downregulation of ACSL3 in U251 cells (human glioma cells) treated with 1.42 μM CN-3 (a new asterosaponin isolated from the starfish Culcita novaeguineae, which is characterized as exhibiting antitumor activities at low concentrations). This evidence concerns the gene ACSL3 and central nervous system cancer.