Another genome-wide meta-analysis on data from European and Chinese populations (84,694 individuals) also found the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease genetics—body weight loss is a frequent complication in ALS patients and is reported to be associated with shorter survival (Iacoangeli et al., 2020). Here, ACSL5 is linked to amyotrophic lateral sclerosis.