ACSL1 and cancer: Several ACSLs-related reviews have summarized the mechanisms and function of the ACSLs in cancer: ACSL1 and ACSL3 may lead to cancer progression and worse prognosis, while ASCL5 and ACSL6 act as key suppressor with the opposite effect (Yan et al., 2015; Kuwata and Hara, 2019; Quan et al., 2021).