Similarly, an investigation focusing on transient cerebral I/R injury revealed that enhanced expression of SIRT1 by NAD+ biosynthesis-related essential enzyme suppressed the relative phosphorylation of mTOR (pmTOR/mTOR) levels in the peri-infarct penumbra, regulated autophagy and alleviated ischemia-induced cortical neurons death in aged ischemic rats (Wang et al., 2019). This evidence concerns the gene SIRT1 and ischemia.