It has been demonstrated that the FOXO family function as a SIRT1 deacetylates member that influences downstream autophagy-related pathways and regulates autophagy in numerous pathophysiological processes of diabetes, obesity, cardiovascular disease, tumor, aging, and other diseases (Zhu et al., 2019; Mao et al., 2021; Rong et al., 2021). This evidence concerns the gene SIRT1 and cardiovascular disorder.