SIRT1 and cardiac arrest: Additionally, another investigation found that mild hypothermia increased the survival rate and ameliorated apoptosis in the cortex of mice after cardiac arrest/cardiopulmonary resuscitation (CA/CPR) through SIRT1-mediated autophagy, whereas inhibition of SIRT1 abolished the neuroprotection of hypothermia both in vivo and in vitro (Wei et al., 2019).