The CSF: serum ratio of IL-6 levels was sufficiently consistent to act as a potential biomarker of intracranial aneurysms (Kaminska et al., 2021), while increased levels of IL-6 in rat brain parenchyma occurred in parallel with plasma and CSF values and with the severity of traumatic brain injury (Chatzipanteli et al., 2012). This evidence concerns the gene IL6 and injury.