- Pro-inflammatory; enhances CCL2 and CXCL1 production and intercellular adhesion (T72) - Controls lymphocyte recruitment into CNS (T73) - Promotes neurodegeneration, damage and dysfunction (T74) - Promotes inflammation and cell loss after stroke (T75) - Contributes to progression of CNS inflammatory disorders (EAE, MS) (T76–T78) - May contribute to Parkinson’s disease (T79) - Raised levels in schizophrenia, with potential role in symptoms (T80) - Promotes autism-like phenotypes in mouse offspring (T81). The gene discussed is CXCL1; the disease is autism.