TAFAZZIN and Barth syndrome: Accumulation of MLCL is observed in the mitochondrial membranes of people with Barth syndrome (BTHS).36 BTHS is caused by a mutation in the tafazzin gene,37 leading to dysfunctional cardiolipin biosynthesis.38 Clinical manifestations of BTHS include growth retardation, skeletal muscle fatigue and cardiomyopathy.39,40 The cellular and molecular basis of BTHS can be attributed to numerous factors, including destabilisation of supercomplexes.41–44