TGFB1 and neoplasm: In conclusion, the involvement of miR-425-5p in reprogramming the microenvironment via inhibition of TGFβRII expression and production of ROS to activate TGFβ1/ROS signaling pathway, thereby promoting tumor growth in normal fibroblasts via EMT, migration, and invasion, in addition to its tumor-growth role (Figure 10), endows this miRNA with a significant therapeutic potential in breast cancer.