The current study, consistent with Mohan et al. [ 21], only assessed non-smokers; hence, pentraxin-3 concentration in the CP group was higher than in the pre-treatment control group, while it significantly decreased after the periodontal therapy. Periodontitis is often diagnosed based on radiographic findings and clinical measurements, which is cost-effective but does not provide any information regarding the current status of disease and prediction of its course in the future. The gene discussed is PTX3; the disease is periodontitis.