[34] Quercetin in PA-1 human ovarian cancer cell line significantly reduces cell viability by a dose-dependent manner, enhances apoptosis of aggressive ovarian cancer cell lines, reduces Bcl-2 and Bcl-xL, increases Bad, Bid, Bax, caspase-3, caspase-9, and cytochrome C, and enhances the mitochondrial-induced pathway of apoptosis, thereby inhibiting the growth of invasive ovarian cancer cells [49]. This evidence concerns the gene CASP3 and ovarian cancer.