Quercetin is effective in the treatment of knee osteoarthritis, and studies have shown that quercetin can alleviate joint damage in rats with knee osteoarthritis by mediating the TSC2-RHBE-mTOR signal pathway and that quercetin inhibits the expression of RHEB, p-mTOR, p-ULK1, and P62 and promotes fibroblast proliferation and migration. Here, RHEB is linked to osteoarthritis, knee.