To be fair, the original developers of the A/T/N classification system stated that it “should not be used in general medical practice as it is premature and inappropriate.” Frisoni et al. (2019, p. 919) go further by saying that we should “refrain from using the Alzheimer’s disease label for cognitively intact people showing abnormal amyloid markers (CSF or PET) but normal or unknown tau markers.” They call this instead “amyloidosis of the brain,” and see this as “a risk marker for neurodegenerative dementia.” The gene discussed is MAPT; the disease is Alzheimer disease.