KEGG enrichment analysis revealed that neuroactive ligand–receptor interaction (hsa04080), cAMP signaling pathway (hsa04024), PI3K-Akt signaling pathway (hsa04151), serotonergic synapse (hsa04726), and dopaminergic synapse (hsa04728) are rich in many targets that may contribute to the treatment of depression with TCEF. Here, AKT1 is linked to depressive disorder.