Based on the understanding of differentially expressed genes, including CCL5, AQP3, and SDC4, combined with the related biological processes and pathways analyzed by bioinformatics, the up-regulation of AQP3 and CCL5 and down-regulation of SDC4 were preliminarily predicted to alleviate the lack of cell nutrient supply, reduce the degradation rate of the external matrix, repair the damaged disc tissue, and slow the progression of disc degeneration. The gene discussed is SDC4; the disease is intervertebral disk degenerative disorder.