THSD7A and osteoporosis: Zhou et al. (2013) found that osteoporotic spinal fracture was closely associated with THSD7A and N substructure of imine methyltransferase. When the single nucleotide polymorphisms (SNP) loci of Rs1267369 and RS760537 in patients were homozygous alleles (AA type), the risk of vertebral fracture was significantly increased. Moreover, Mori et al. (2008) found that genetic variation of THSD7A and THSD4 was the decisive factor leading to osteoporosis in Japanese women.