Collectively, we demonstrated that SOL downregulated the PI3K/AKT/mTOR signaling pathway to suppress NSCLC cell growth (i.e.,: cell proliferation, migration, and invasion) and activated caspase-3 and PARP-1 to promote cell apoptosis by inducing ROS production (Figure 13). The gene discussed is CASP3; the disease is non-small cell lung carcinoma.