In APP/PS1 mice, fruitless Lycium barbarum sprout extract also shows potential for the treatment of AD; it could significantly inhibit Aβ fibrillation, decompose the formed Aβ fibers, reduce Aβ oligomer levels and Aβ-induced neurotoxicity, and attenuate oxidative stress in vitro (Liu S. Y. et al., 2018). This evidence concerns the gene PSEN1 and Alzheimer disease.