Bergamot essential oil (BEO), one of the most common essential oils, is composed of volatile aromatic terpenes and oxygenated derivatives such as linalool, and previous studies have demonstrated the neuroprotective and anti-inflammatory properties of BEO (Scuteri et al., 2019).The inhalation of BEO for 21 days alleviated the cognitive behavioral impairment of AD mice and reduced Aβ content and AChE activity in the hippocampus and cortex in D-gal- and aluminum-trichloride-treated AD mice (Hu et al., 2022). The gene discussed is ACHE; the disease is Alzheimer disease.