The relevant mechanisms of action include significantly reducing toxic Aβ1-42 deposition; activating microglia in the brain; reducing the levels of the proinflammatory factors IL-1β, IL-6 and TNF-α; improving gut barrier integrity and the gut microbiota; reversing the ratio of Bacteroides to Firmicutes; eliminating Clostridium and Streptococcus, which may be associated with cognitive deficit; and reducing the levels of proinflammatory cytokines in the peripheral circulation, especially IL-1α, IL-6, IL-17A, and IL-12 (Xie Z. et al., 2020). This evidence concerns the gene TNF and Cognitive impairment.