The combined use of ginsenoside Rb1 and Rg1 reduces brain Aβ production by modulating multiple factors, including the NLRP3 inflammasome, TNF-α, oxidative stress, astrocytes, and microglial plasma cell activation, and improves cognitive impairment in SAMP8 mice (Yang Y. et al., 2020). This evidence concerns the gene TNF and Cognitive impairment.