Turmeric is the dried rhizome of the ginger plant Curcuma longa L. Curcumin is a phenolic pigment extracted from turmeric, Zedoary turmeric, curcuma, etc. The mechanisms by which curcumin alters AD pathology include the following: curcumin inhibits the formation of Aβ plaques and promotes their breakdown, attenuates tau hyperphosphorylation and enhances tau clearance, binds copper, lowers cholesterol, modulates microglial activity, inhibits AChE, modulates insulin signaling and acts an antioxidant (Tang and Taghibiglou, 2017). Here, MAPT is linked to Alzheimer disease.