Possible molecular mechanisms by which geniposide protects the brain from AD pathological damage are reducing amyloid plaques, inhibiting tau phosphorylation, preventing memory impairment and synaptic loss, reducing oxidative stress and chronic inflammatory responses, and promoting neurite outgrowth through the glucagon-like peptide-1 receptor (GLP-1R) signaling pathway (Liu et al., 2015). This evidence concerns the gene MAPT and Alzheimer disease.