Curcumin can improve learning and memory ability, downregulate the level of HMGB1, and reduce the expression of downstream RAGE and TLRs, which in turn reduces the expression of downstream NF-κB in the hippocampus and alleviates AD symptoms in 4-month-old APP/PS1 AD mice (Han et al., 2018). This evidence concerns the gene AGER and Alzheimer disease.