NFKB1 and Alzheimer disease: Some studies have found that BHD can block the initiation of the inflammatory response; reduce the expression of the inflammatory factors IL-1β, TNF-α and IL-1 by reducing the content of NF-κB in the brains of AD transgenic mice; inhibit the CNS; restrain the nervous system inflammatory response; and reduce cognitive and memory impairment in model mice (Yu et al., 2017).