PSEN1 and Alzheimer disease: It can improve cognition and memory, which may be related to reducing the levels of Aβ and tau hyperphosphorylation by inhibiting the glycogen synthase kinase (GSK) 3β (GSK3β) signaling pathway in the cerebral cortex in APP/PS1 mice (Mei et al., 2016).Studies have shown that Pueraria lobata can attenuate Aβ1-42-induced tau hyperphosphorylation in SH-SY5Y cells by inhibiting the expression of GSK-3β and activating the Wnt/β-catenin signaling pathway; therefore, Pueraria lobata may have a protective effect against AD (Yao et al., 2017).