For example, human albumin is excreted by the kidney during kidney injury, so supplementing with human albumin can aggravate kidney injury, resulting in further damage to already damaged kidneys, a worsened glomerular basement membrane charge barrier and mechanical barrier, as well as an increase in protein leakage, which may be a risk factor for vancomycin-associated AKI (Kimura et al., 2021). The gene discussed is ALB; the disease is acute kidney injury.